A general model for binary cell fate decision gene circuits with degeneracy: indeterminacy and switch behavior in the absence of cooperativity.

BACKGROUND: The gene regulatory circuit motif in which two opposing fate-determining transcription factors inhibit each other but activate themselves has been used in mathematical models of binary cell fate decisions in multipotent stem or progenitor cells.This simple circuit can generate multistability and explains the symmetric "poised" precursor

read more


Sterile osteomyelitis in the ulnar diaphysis of a young indoor cat

Case summary Ointments A 3-year-old neutered male indoor British Shorthair cat was referred for a 2-week history of intermittent right forelimb lameness.Radiographic examination showed a diaphyseal monostotic, expansile, fusiform, lytic lesion in the right ulna.CT further defined the lesion and also demonstrated ipsilateral pulmonary consolidation.

read more